Automated VUS Reclassification Alerts
Every morning, WebRun opens Progeny Clinical, compares each patient's recorded variant classification against yesterday's, logs any change to a Google Sheet with the old and new classification, and posts a Slack alert to the clinical team ranked by whether the variant moved toward pathogenic or benign.
How do I make sure my clinic catches every variant reclassification quickly?
WebRun compares every patient's variant classification in Progeny Clinical each morning against the previous day's value, logs any reclassification to a Google Sheet with the old and new tier, and posts a Slack alert to the clinical team ranked by urgency. Upgrades toward pathogenic surface first, so no reclassification waits for someone to notice it by chance.
- No variant reclassification goes unnoticed between visits
- Upgrades toward pathogenic reach the clinical team the same morning
- Every change is logged with its old and new classification for the record
Built for genetic counselors · medical geneticists · clinical genetics teams · genetics practice managers
What does WebRun do on every run?
The exact actions WebRun takes, in order - in plain language, so you can adjust anything.
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WebRun signs in and gets to work
Opens
app.progenygenetics.comin a real browser with your saved login - no setup, no API keys. -
1
Progeny Clinical - find changed variant classifications
progenygenetics.com
WebRun opens Progeny Clinical to find changed variant classifications. - Open Progeny Clinical and pull the current variant classification for every active patient
- Compare each classification against the value recorded on the previous run
- Flag every patient whose classification changed since yesterday
Done when Every patient with a changed variant classification is identified with the old and new values.
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2
Google Sheets - log the reclassification
google.com
WebRun opens Google Sheets to log the reclassification. - Open the VUS Reclassification Log sheet
- Append a new row for each changed patient with the date, old classification, and new classification
- Mark whether the change moved toward pathogenic, toward benign, or between two uncertain tiers
Done when The log sheet has a dated row for every reclassification found today.
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3
Slack - alert the clinical team
slack.com
WebRun opens Slack to alert the clinical team. - Post an alert to the clinical Slack channel listing today's reclassifications
- Put upgrades toward pathogenic at the top since they need the fastest follow up
- Link to the full Google Sheets log for the details
Done when The clinical team has today's reclassification alert in Slack, ranked by urgency.
How is each run configured?
Secure by default
Connect once, stays signed in
WebRun signs in once and keeps each session in a persistent environment, so every run picks up right where it left off.
Every action is checked against this policy before it runs.
Questions, answered
Does it contact the patient about the reclassification?
No. WebRun only logs the change and alerts your clinical team internally in Slack. A genetic counselor decides how and when to reach the patient or the ordering provider.
How does it know a classification actually changed?
It compares each patient's current variant classification in Progeny Clinical against the value from the previous run, so only genuine changes get logged and alerted.
Which reclassifications get flagged as most urgent?
Any variant that moved toward pathogenic is listed first in the Slack alert, since those usually need the fastest clinical follow up.
Related templates
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